Pathophysiology - I





Unit – I

1. Introduction to Pathophysiology

2. Basic Principles Of Cell Injury & Adaption

Introduction, definitions, Homeostasis, Components and Types of Feedback systems, Causes of cellular injury,Pathogenesis (Cell membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage),Morphology of cell injury – Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia),Cell swelling, Intra cellular accumulation, Calcification, Enzyme leakage and Cell Death Acidosis &Alkalosis,Electrolyte imbalance

3. Basic Mechanism Involved in the Process of Inflammation, Repair & Atherosclerosis

Introduction, Clinical signs of inflammation, Different types of Inflammation,Mechanism of Inflammation – Alteration in vascular permeability and blood flow, migration of WBC’s,Mediators of inflammation,Basic principles of wound healing in the skin,Pathophysiology of Atherosclerosis






Unit – II

1. Cardiovascular System

Hypertension, congestive heart failure, ischemic heart disease (angina,myocardial infarction, atherosclerosis and arteriosclerosis)

2. Respiratory System

Asthma, Chronic obstructive airways diseases.

3. Renal System

Acute and chronic renal failure






Unit – III

1. Haematological Diseases

2. Endocrine System

3. Nervous System

4. Gastrointestinal System






Unit – IV

1. Inflammatory Bowel & Liver Diseases

2. Diseases Of Bones & Joints

3. Principles Of Cancer






Unit – V

1.Infectious Diseases

2. Sexually Transmitted Diseases