Pharmaceutical Organic Chemistry - I





Unit – I

1. Classification, Nomenclature & Isomerism

Know about Classification of Organic Compounds and IUPAC systems of nomenclature for this organic compounds. And also know about Structural isomerisms in organic compounds.






Unit – II

1. Alkanes, Alkenes & Conjugated Dienes

SP3 hybridization of alkanes, Halogenation of alkanes, Uses of paraffins.
Stabilities of alkenes, SP2 hybridization of alkenes.
E1 and E2 reactions and it’s kinetics order of reactivity in an alkyl halides molecules and rearrangement of carbocations Saytzeffs orientation and evidences. E1 verses E2 reactions Factors affecting E1 and E2 reactions. Ozonolysis and electrophilic addition reactions of alkenes Markownikoff’s orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation.
Stability of conjugated dienes, electrophilic addition, Diel-Alder, free radical addition Reactions of conjugated dienes, allylic rearrangement.






Unit – III

1. Alkyl Halides (Haloalkanes)

SN1 and SN2 reactions and it’s kinetics order of reactivity for alkyl halides molecules and also, stereochemistry and rearrangement of carbocations molecules.
SN1 versus SN2 reactions and Factors affecting of SN1 and SN2 reactions.
Structure and uses of Chloroform,ethylchloride, trichloroethylene, tetrachloroethylene,tetrachloromethane, dichloromethane and iodoform.

2. Alcohols

Qualitative tests, Uses and Structure of Ethyl alcohol, Chlorobutanol,Methyl alcohol, Cetosteryl alcohol, Glycerol, Benzyl alcohol, Propylene glycol.






Unit – IV

1. Carbonyl Compounds (Aldehydes & Ketones)

Nucleophilic addition reactions, Electromeric effect, Aldol condensation, Crossed Aldol condensation and Cannizzaro reaction Crossed Cannizzaro reaction, Benzoin condensation, Perkin condensation, Qualitative tests, Uses and Structure of Formaldehyde, Acetone Paraldehyde, Chloral hydrate, Vanillin ,Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde.






Unit – V

1. Carboxylic Acids

Acidity and effect of substitutions of carboxylic acids and their inductive effect and qualitative tests for carboxylic acids on amide and ester also.
Structure and Uses of Lactic acid, Acetic acid, Succinic acid,Tartaric acid, Citric acid, Salicylic acid, Oxalic acid, Benzoic acid,Methyl salicylate, Benzyl benzoate, Dimethyl phthalate, Methyl salicylate and Acetyl salicylic acid.

2. Aliphatic Amines

Basicity and effect of substituent on Basicity. Qualitative test Structure and uses of Ethylenediamine, Ethanolamine, Amphetamine.